- 2021 Cook Out Southern 500 Results Stock Car Online Results Reference
- 2021 Cook Out Southern 500 Results Stock Car Online Results Reference
| fin | qual | driver | team | laps led | car | sponsor | pts | laps | status |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | Denny Hamlin | Joe Gibbs Racing | 146 | #11 Toyota Camry | Offerpad | 57 | 367 | Finish |
| 2 | 6 | Kyle Larson | Hendrick Motorsports | 156 | #5 Chevy Camaro | HendrickCars.com | 54 | 367 | Finish |
| 3 | 23 | Ross Chastain | Chip Ganassi Racing | 1 | #42 Chevy Camaro | McDonald's | 44 | 367 | Finish |
| 4 | 10 | Martin Truex Jr | Joe Gibbs Racing | 1 | #19 Toyota Camry | Bass Pro | 38 | 367 | Finish |
| 5 | 9 | Kevin Harvick | Stewart-Haas Racing | 20 | #4 Ford Mustang | Busch Light Fan Design | 44 | 367 | Finish |
| 6 | 3 | Kurt Busch | Chip Ganassi Racing | 13 | #1 Chevy Camaro | Monster Energy | 44 | 367 | Finish |
| 7 | 16 | Brad Keselowski | Team Penske | 0 | #2 Ford Mustang | Discount Tire | 30 | 367 | Finish |
| 8 | 11 | Joey Logano | Team Penske | 0 | #22 Ford Mustang | Shell Pennzoil | 34 | 367 | Finish |
| 9 | 34 | Chris Buescher | RFK Racing | 0 | #17 Ford Mustang | Roush Performance | 28 | 367 | Finish |
| 10 | 21 | Austin Dillon | Richard Childress Racing | 0 | #3 Chevy Camaro | Bass Pro Shops / Tracker Off Road | 27 | 367 | Finish |
| 11 | 31 | Cole Custer | Stewart-Haas Racing | 0 | #41 Ford Mustang | HaasTooling.com Demo Day | 26 | 367 | Finish |
| 12 | 18 | Ryan Preece | JTG Daugherty Racing | 0 | #37 Chevy Camaro | Kroger/ Hershey's S'mores | 25 | 367 | Finish |
| 13 | 26 | Daniel Suárez | Trackhouse Racing | 0 | #99 Chevy Camaro | Good Sam | 24 | 367 | Finish |
| 14 | 19 | Ryan Newman | RFK Racing | 0 | #6 Ford Mustang | Oscar Mayer Bologna | 23 | 367 | Finish |
| 15 | 25 | Corey LaJoie | Spire Motorsports | 0 | #7 Chevy Camaro | Schluter Systems | 23 | 367 | Finish |
| 16 | 8 | Aric Almirola | Stewart-Haas Racing | 0 | #10 Ford Mustang | Smithfield | 24 | 366 | Finish |
| 17 | 29 | Ricky Stenhouse Jr | JTG Daugherty Racing | 0 | #47 Chevy Camaro | Kroger/ Little Hug | 20 | 366 | Finish |
| 18 | 7 | Tyler Reddick | Richard Childress Racing | 0 | #8 Chevy Camaro | Childress Vineyards | 23 | 366 | Finish |
| 19 | 24 | Chase Briscoe | Stewart-Haas Racing | 0 | #14 Ford Mustang | HighPoint.com / Founders | 18 | 366 | Finish |
| 20 | 13 | Christopher Bell | Joe Gibbs Racing | 10 | #20 Toyota Camry | SportClips Haircuts | 26 | 366 | Finish |
| 21 | 17 | Bubba Wallace | 23XI Racing | 0 | #23 Toyota Camry | Door Dash | 16 | 366 | Finish |
| 22 | 1 | Ryan Blaney | Team Penske | 17 | #12 Ford Mustang | Menards \ Richmond | 24 | 366 | Finish |
| 23 | 30 | Matt DiBenedetto | Wood Brothers Racing | 0 | #21 Ford Mustang | Motorcraft/Quick Lane | 14 | 365 | Finish |
| 24 | 32 | Anthony Alfredo | Front Row Motorsports | 0 | #38 Ford Mustang | Chicago Pneumatic Compressors | 13 | 364 | Finish |
| 25 | 20 | Justin Haley | Spire Motorsports | 0 | #77 Chevy Camaro | Bon Secours/Swamp Rabbits | 0 | 364 | Finish |
| 26 | 5 | Alex Bowman | Hendrick Motorsports | 0 | #48 Chevy Camaro | Ally | 11 | 363 | Finish |
| 27 | 27 | BJ McLeod | Live Fast Motorsports | 0 | #78 Ford Mustang | CorvetteParts.net | 0 | 359 | Finish |
| 28 | 28 | Josh Bilicki | Rick Ware Racing | 0 | #52 Ford Mustang | Junction Fuels Throwback | 9 | 359 | Finish |
| 29 | 35 | Joey Gase | Rick Ware Racing | 1 | #15 Chevy Camaro | RWR | 0 | 357 | Finish |
| 30 | 37 | Quin Houff | StarCom Racing | 0 | #00 Chevy Camaro | UNITS | 7 | 355 | Finish |
| 31 | 4 | Chase Elliott | Hendrick Motorsports | 0 | #9 Chevy Camaro | NAPA/Children's | 9 | 327 | Accident |
| 32 | 22 | Erik Jones | Legacy Motor Club | 2 | #43 Chevy Camaro | Petty's Garage | 5 | 264 | Engine |
| 33 | 33 | Cody Ware | Rick Ware Racing | 0 | #51 Chevy Camaro | Nurtec ODT | 0 | 209 | Accident |
| 34 | 14 | William Byron | Hendrick Motorsports | 0 | #24 Chevy Camaro | Axalta | 3 | 199 | Accident |
| 35 | 12 | Kyle Busch | Joe Gibbs Racing | 0 | #18 Toyota Camry | M&M's | 2 | 125 | Accident |
| 36 | 36 | James Davison | Rick Ware Racing | 0 | #53 Chevy Camaro | Jacobs Companies | 1 | 50 | Accident |
| 37 | 15 | Michael McDowell | Front Row Motorsports | 0 | #34 Ford Mustang | Love's Travel Stops | 1 | 30 | Accident |